At the Mobile World Congress 2010, HTC showed their new updated HTC Sense UI to debut on the HTC Desire and HTC Legend, with an upgrade available for the Hero and Magic. The new version is based upon Android 2.1 and has new interface features such as the Friend Stream widget (which aggregates all Twitter, Facebook and Flickr information) and Leap, which allows access to all the home screens at once.

While the Windows Mobile version of Sense is the successor to TouchFLO 3D, with information featured on separate tabs. The Android version presents information through Android desktop widgets and applications, and includes launcher, app drawer, and lock screen replacements.

The Today screen plugin is the main aspect of Sense, and consists of several tabs, which can be viewed by sliding a finger along the bottom bar or touching one of the visible icons. The Messages, Email and Calendar icons update to show the number of unread SMS/MMS messages, the number of unread emails and the current date respectively. Several applications, such as HTC Messages, are closely linked to the Today screen plugin to provide a seamless experience. The tabs to the immediate right and left of the current tab can be accessed by swiping in the relevant direction. The tabs in Sense 2.5 are:

Each tab has two soft keys which provide access to functions associated with a tab or tab customisation.

HTC Espresso is an internal code name for an Android smartphone which features a modified user interface based on the Sense UI. It has some key differences from HTC Sense, which include bubbled icons and a new Genius voice control system. The phone is currently marketed by T-Mobile USA as the myTouch 3G Slide.